SH2B3

GENE INFORMATION

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Gene name

SH2B3 (HGNC Symbol)

Synonyms

IDDM20, LNK

Description

SH2B adaptor protein 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Chromosome

12

Cytoband

q24.12

Chromosome location (bp)

111405948 - 111451623

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111252 (version 78.38)

Entrez gene

10019

UniProt

Q9UQQ2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UQQ2

Antibodypedia

SH2B3 antibodies
 

PROTEIN VIEW

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SH2B3-001
 
SH2B3-002
 
SH2B3-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH2B3-001 ENSP00000345492
ENST00000341259
Q9UQQ2
Show all »
Show » Show » 575 63.2 No 0
SH2B3-002 ENSP00000440597
ENST00000538307
F5GYM4
Show all »
Show » 373 41.4 No 0
SH2B3-003 ENSP00000473529
ENST00000550925
Show » Show » 217 23.6 No 0