GTF2H3 - Gene info - The Human Protein Atlas

GTF2H3

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	GTF2H3 (HGNC Symbol)
Synonyms	BTF2, P34, TFIIH
Description	General transcription factor IIH, polypeptide 3, 34kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	123633739 - 123662606
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111358 (version 78.38)
Entrez gene	2967
UniProt	Q13889 (UniProt - Evidence at protein level)
neXtProt	NX_Q13889
Antibodypedia	GTF2H3 antibodies

PROTEIN VIEW

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GTF2H3-001		GTF2H3-002		GTF2H3-003		GTF2H3-004		GTF2H3-008		GTF2H3-011		GTF2H3-013		GTF2H3-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
GTF2H3-001	ENSP00000445162 ENST00000543341	Q13889 Show all » « Hide Q13889 [Direct mapping] General transcription factor IIH subunit 3	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0000718 [nucleotide-excision repair, DNA damage removal] GO:0003684 [damaged DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004672 [protein kinase activity] GO:0005654 [nucleoplasm] GO:0005675 [holo TFIIH complex] GO:0006200 [ATP catabolic process] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0006412 [translation] GO:0006468 [protein phosphorylation] GO:0008094 [DNA-dependent ATPase activity] GO:0008135 [translation factor activity, nucleic acid binding] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0050434 [positive regulation of viral transcription]	308	34.4	No	0
GTF2H3-002	ENSP00000228955 ENST00000228955	Q13889 Show all » « Hide Q13889 [Direct mapping] General transcription factor IIH subunit 3	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0000718 [nucleotide-excision repair, DNA damage removal] GO:0003684 [damaged DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004672 [protein kinase activity] GO:0005654 [nucleoplasm] GO:0005675 [holo TFIIH complex] GO:0006200 [ATP catabolic process] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0006412 [translation] GO:0006468 [protein phosphorylation] GO:0008094 [DNA-dependent ATPase activity] GO:0008135 [translation factor activity, nucleic acid binding] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0050434 [positive regulation of viral transcription]	267	29.8	No	0
GTF2H3-003	ENSP00000446097 ENST00000538845	F5H4K7 Show all » « Hide F5H4K7 [Target identity:100%; Query identity:100%] General transcription factor IIH subunit 3 {ECO:0000313\|Ensembl:ENSP00000446097}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated]	210	23.6	No	0
GTF2H3-004	ENSP00000446429 ENST00000539994	F5GXG6 Show all » « Hide F5GXG6 [Target identity:100%; Query identity:100%] General transcription factor IIH subunit 3 {ECO:0000313\|Ensembl:ENSP00000446429}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated]	177	19.8	No	0
GTF2H3-008	ENSP00000438435 ENST00000543154	H0YFF7 Show all » « Hide H0YFF7 [Target identity:100%; Query identity:100%] General transcription factor IIH subunit 3 {ECO:0000313\|Ensembl:ENSP00000438435}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated]	194	21.9	No	0
GTF2H3-011	ENSP00000441894 ENST00000536375	F5GWD3 Show all » « Hide F5GWD3 [Target identity:100%; Query identity:100%] General transcription factor IIH subunit 3 {ECO:0000313\|Ensembl:ENSP00000441894}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated]	258	28.9	No	0
GTF2H3-013	ENSP00000442977 ENST00000538533	F5H6X0 Show all » « Hide F5H6X0 [Target identity:100%; Query identity:100%] General transcription factor IIH subunit 3 {ECO:0000313\|Ensembl:ENSP00000442977}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated]	148	16.4	No	0
GTF2H3-201	ENSP00000481711 ENST00000618160		Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000439 [core TFIIH complex] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated]	162	18.2	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.