CHD4

GENE INFORMATION

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Gene name

CHD4 (HGNC Symbol)

Synonyms

Mi-2b, Mi2-BETA

Description

Chromodomain helicase DNA binding protein 4 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6570083 - 6607476

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111642 (version 78.38)

Entrez gene

1108

UniProt

Q14839 (UniProt - Evidence at protein level)

neXtProt

NX_Q14839

Antibodypedia

CHD4 antibodies
 

PROTEIN VIEW

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CHD4-002
 
CHD4-003
 
CHD4-004
 
CHD4-013
 
CHD4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHD4-002 ENSP00000440542
ENST00000544040
F5GWX5
Show all »
Show » Show » 1905 217.1 No 0
CHD4-003 ENSP00000437506
ENST00000545942
F5H6N4
Show all »
Show » Show » 354 39.1 No 0
CHD4-004 ENSP00000444614
ENST00000545584
F5H596
Show all »
Show » Show » 125 13.8 No 0
CHD4-013 ENSP00000440392
ENST00000544484
Q14839
Show all »
Show » Show » 1937 220.5 No 0
CHD4-201 ENSP00000349508
ENST00000357008
Q14839
Show all »
Show » Show » 1912 218 No 0