USP5

GENE INFORMATION

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Gene name

USP5 (HGNC Symbol)

Synonyms

IsoT

Description

Ubiquitin specific peptidase 5 (isopeptidase T) (HGNC Symbol)

Entrez gene summary

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6852128 - 6866632

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111667 (version 78.38)

Entrez gene

8078

UniProt

P45974 (UniProt - Evidence at protein level)

neXtProt

NX_P45974

Antibodypedia

USP5 antibodies
 

PROTEIN VIEW

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USP5-001
 
USP5-002
 
USP5-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP5-001 ENSP00000229268
ENST00000229268
P45974
Show all »
Show » Show » 858 95.8 No 0
USP5-002 ENSP00000373883
ENST00000389231
P45974
Show all »
Show » Show » 835 93.3 No 0
USP5-003 ENSP00000444668
ENST00000542087
F5H571
Show all »
Show » 137 15.7 No 0