PRKAB1

GENE INFORMATION

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Gene name

PRKAB1

Synonyms

Description

Protein kinase, AMP-activated, beta 1 non-catalytic subunit (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q24.23

Chromosome location (bp)

119667753 - 119681630

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111725 (version 78.38)

Entrez gene

5564

UniProt

Q9Y478 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y478

Antibodypedia

PRKAB1 antibodies
 

PROTEIN VIEW

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PRKAB1-001
 
PRKAB1-002
 
PRKAB1-005
 
PRKAB1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKAB1-001 ENSP00000229328
ENST00000229328
Q9Y478
Show all »
Show » Show » 270 30.4 No 0
PRKAB1-002 ENSP00000441369
ENST00000541640
Q9Y478
Show all »
Show » Show » 270 30.4 No 0
PRKAB1-005 ENSP00000439235
ENST00000540121
F5H2X8
Show all »
Show » Show » 104 11.7 No 0
PRKAB1-006 ENSP00000437993
ENST00000545223
F5H610
Show all »
Show » Show » 62 6.8 No 0