IL17A

GENE INFORMATION

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Gene name

IL17A (HGNC Symbol)

Synonyms

CTLA8, IL-17, IL-17A, IL17

Description

Interleukin 17A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p12.2

Chromosome location (bp)

52186387 - 52190638

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112115 (version 78.38)

Entrez gene

3605

UniProt

Q16552 (UniProt - Evidence at protein level)

neXtProt

NX_Q16552

Antibodypedia

IL17A antibodies
 

PROTEIN VIEW

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IL17A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL17A-001 ENSP00000344192
ENST00000340057
Q16552
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