MCM3

GENE INFORMATION

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Gene name

MCM3

Synonyms

Description

Minichromosome maintenance complex component 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

6

Cytoband

p12.2

Chromosome location (bp)

52264009 - 52284881

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112118 (version 78.38)

Entrez gene

4172

UniProt

P25205 (UniProt - Evidence at protein level)

neXtProt

NX_P25205

Antibodypedia

MCM3 antibodies
 

PROTEIN VIEW

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MCM3-001
 
MCM3-004
 
MCM3-006
 
MCM3-201
 
MCM3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MCM3-001 ENSP00000472940
ENST00000596288
B4DWW4
Show all »
Show » Show » 853 95.9 No 0
MCM3-004 ENSP00000407651
ENST00000421471
Q7Z6P5
Show all »
Show » Show » 328 37.4 No 0
MCM3-006 ENSP00000229854
ENST00000229854
P25205
Show all »
Show » Show » 808 91 No 0
MCM3-201 ENSP00000388647
ENST00000419835
J3KQ69
Show all »
Show » Show » 818 91.9 No 0
MCM3-202 ENSP00000480987
ENST00000616552
B4DWW4
Show all »
Show » Show » 853 95.9 No 0