FIG4

GENE INFORMATION

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Gene name

FIG4 (HGNC Symbol)

Synonyms

ALS11, CMT4J, dJ249I4.1, hSac3, KIAA0274, SAC3

Description

FIG4 phosphoinositide 5-phosphatase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q21

Chromosome location (bp)

109691312 - 109825428

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112367 (version 78.38)

Entrez gene

9896

UniProt

Q92562 (UniProt - Evidence at protein level)

neXtProt

NX_Q92562

Antibodypedia

FIG4 antibodies
 

PROTEIN VIEW

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FIG4-001
 
FIG4-002
 
FIG4-003
 
FIG4-004
 
FIG4-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FIG4-001 ENSP00000230124
ENST00000230124
Q92562
Show all »
Show » Show » 907 103.6 No 1
FIG4-002 ENSP00000405660
ENST00000415980
Show » 136 16 No 0
FIG4-003 ENSP00000396566
ENST00000419951
Q5JRV4
Show all »
Show » 99 10.5 No 0
FIG4-004 ENSP00000412156
ENST00000454215
Q5TCS5
Show all »
Show » Show » 237 27.5 No 1
FIG4-005 ENSP00000357937
ENST00000368941
Q5TCS4
Show all »
Show » Show » 139 15.9 No 1