EXOC2

GENE INFORMATION

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Gene name

EXOC2 (HGNC Symbol)

Synonyms

FLJ11026, SEC5L1, Sec5p

Description

Exocyst complex component 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

6

Cytoband

p25.3

Chromosome location (bp)

485133 - 693111

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112685 (version 78.38)

Entrez gene

55770

UniProt

Q96KP1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96KP1

Antibodypedia

EXOC2 antibodies
 

PROTEIN VIEW

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EXOC2-002
 
EXOC2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EXOC2-002 ENSP00000230449
ENST00000230449
Q96KP1
Show all »
Show » Show » 924 104.1 No 0
EXOC2-003 ENSP00000406400
ENST00000443083
Q2MDF5
Show all »
Show » Show » 140 15.2 No 0