NR3C1 - Gene info - The Human Protein Atlas

NR3C1

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	NR3C1 (HGNC Symbol)
Synonyms	GR, GRL
Description	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (HGNC Symbol)
Entrez gene summary	This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	143277931 - 143435512
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113580 (version 78.38)
Entrez gene	2908
UniProt	P04150 (UniProt - Evidence at protein level)
neXtProt	NX_P04150
Antibodypedia	NR3C1 antibodies

PROTEIN VIEW

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NR3C1-001		NR3C1-002		NR3C1-003		NR3C1-004		NR3C1-005		NR3C1-006		NR3C1-007		NR3C1-008		NR3C1-009		NR3C1-010		NR3C1-013		NR3C1-201		NR3C1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NR3C1-001	ENSP00000231509 ENST00000231509	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor E5KQF6 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|EMBL:ADP91136.1}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_a {ECO:0000313\|EMBL:EAW61870.1} D6RDA9 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006111 [regulation of gluconeogenesis] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008211 [glucocorticoid metabolic process] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016568 [chromatin modification] GO:0030325 [adrenal gland development] GO:0031946 [regulation of glucocorticoid biosynthetic process] GO:0042711 [maternal behavior] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0060603 [mammary gland duct morphogenesis] GO:1900170 [negative regulation of glucocorticoid mediated signaling pathway]	778	85.8	No	0
NR3C1-002	ENSP00000377977 ENST00000394464	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor F1D8N4 [Target identity:100%; Query identity:100%] Glucocorticoid nuclear receptor variant 1 {ECO:0000313\|EMBL:ADZ17333.1} B7Z7I2 [Target identity:48%; Query identity:100%] cDNA FLJ50281, highly similar to Glucocorticoid receptor {ECO:0000313\|EMBL:BAH13618.1} D6RDA9 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	777	85.7	No	0
NR3C1-003	ENSP00000387672 ENST00000415690	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor E5KQF5 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|EMBL:ADP91134.1}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_b {ECO:0000313\|EMBL:EAW61871.1} D6RDA9 [Target identity:19%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:19%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	742	81.5	No	0
NR3C1-004	ENSP00000424747 ENST00000510170	Q3MSN4 Show all » « Hide Q3MSN4 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1} D6RDA9 [Target identity:99%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway]	145	15.4	No	0
NR3C1-005	ENSP00000425313 ENST00000508760	Q3MSN4 Show all » « Hide Q3MSN4 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1} D6RDA9 [Target identity:99%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway]	145	15.4	No	0
NR3C1-006	ENSP00000377979 ENST00000394466	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor E5KQF6 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|EMBL:ADP91136.1}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_a {ECO:0000313\|EMBL:EAW61870.1} D6RDA9 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	778	85.8	No	0
NR3C1-007	ENSP00000427672 ENST00000503201	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor F1D8N4 [Target identity:100%; Query identity:100%] Glucocorticoid nuclear receptor variant 1 {ECO:0000313\|EMBL:ADZ17333.1} B7Z7I2 [Target identity:48%; Query identity:100%] cDNA FLJ50281, highly similar to Glucocorticoid receptor {ECO:0000313\|EMBL:BAH13618.1} D6RDA9 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	777	85.7	No	0
NR3C1-008	ENSP00000420856 ENST00000502892	Q3MSN4 Show all » « Hide Q3MSN4 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1} D6RDA9 [Target identity:99%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway]	145	15.4	No	0
NR3C1-009	ENSP00000426478 ENST00000514699	Q3MSN4 Show all » « Hide Q3MSN4 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1} D6RDA9 [Target identity:99%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway]	145	15.4	No	0
NR3C1-010	ENSP00000422518 ENST00000504572	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor E5KQF6 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|EMBL:ADP91136.1}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_a {ECO:0000313\|EMBL:EAW61870.1} D6RDA9 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	778	85.8	No	0
NR3C1-013	ENSP00000425374 ENST00000502500	D6RDA9 Show all » « Hide D6RDA9 [Target identity:100%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway]	144	15.3	No	0
NR3C1-201	ENSP00000343205 ENST00000343796	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor F1D8N4 [Target identity:100%; Query identity:100%] Glucocorticoid nuclear receptor variant 1 {ECO:0000313\|EMBL:ADZ17333.1} B7Z7I2 [Target identity:48%; Query identity:100%] cDNA FLJ50281, highly similar to Glucocorticoid receptor {ECO:0000313\|EMBL:BAH13618.1} D6RDA9 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:18%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	777	85.7	No	0
NR3C1-202	ENSP00000405282 ENST00000424646	P04150 Show all » « Hide P04150 [Direct mapping] Glucocorticoid receptor B7Z7I2 [Target identity:50%; Query identity:100%] cDNA FLJ50281, highly similar to Glucocorticoid receptor {ECO:0000313\|EMBL:BAH13618.1} D6RDA9 [Target identity:19%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000425374} Q3MSN4 [Target identity:19%; Query identity:100%] Glucocorticoid receptor {ECO:0000313\|Ensembl:ENSP00000420856}; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313\|EMBL:CAI46894.1}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004883 [glucocorticoid receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043402 [glucocorticoid mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	751	82.9	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.