LIFR

GENE INFORMATION

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Gene name

LIFR (HGNC Symbol)

Synonyms

CD118

Description

Leukemia inhibitory factor receptor alpha (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

p13.1

Chromosome location (bp)

38474963 - 38608354

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113594 (version 78.38)

Entrez gene

3977

UniProt

P42702 (UniProt - Evidence at protein level)

neXtProt

NX_P42702

Antibodypedia

LIFR antibodies
 

PROTEIN VIEW

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LIFR-001
 
LIFR-003
 
LIFR-004
 
LIFR-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIFR-001 ENSP00000263409
ENST00000263409
P42702
Show all »
Show » Show » 1097 123.7 Yes 1
LIFR-003 ENSP00000398368
ENST00000453190
P42702
Show all »
Show » Show » 1097 123.7 Yes 1
LIFR-004 ENSP00000426685
ENST00000506990
D6RF33
Show all »
Show » Show » 126 14.5 Yes 0
LIFR-005 ENSP00000427310
ENST00000511561
D6RJ94
Show all »
Show » Show » 75 8.8 Yes 0