H2AFY - Gene info - The Human Protein Atlas

H2AFY

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	H2AFY (HGNC Symbol)
Synonyms	macroH2A1.2
Description	H2A histone family, member Y (HGNC Symbol)
Entrez gene summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	135333900 - 135399914
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113648 (version 78.38)
Entrez gene	9555
UniProt	O75367 (UniProt - Evidence at protein level)
neXtProt	NX_O75367
Antibodypedia	H2AFY antibodies

PROTEIN VIEW

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H2AFY-001		H2AFY-002		H2AFY-003		H2AFY-004		H2AFY-005

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
H2AFY-001	ENSP00000423563 ENST00000511689	O75367 Show all » « Hide O75367 [Direct mapping] Core histone macro-H2A.1	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000182 [rDNA binding] GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0000793 [condensed chromosome] GO:0001739 [sex chromatin] GO:0001740 [Barr body] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005721 [pericentric heterochromatin] GO:0005730 [nucleolus] GO:0006334 [nucleosome assembly] GO:0007549 [dosage compensation] GO:0010385 [double-stranded methylated DNA binding] GO:0016568 [chromatin modification] GO:0019901 [protein kinase binding] GO:0030291 [protein serine/threonine kinase inhibitor activity] GO:0031490 [chromatin DNA binding] GO:0033128 [negative regulation of histone phosphorylation] GO:0035098 [ESC/E(Z) complex] GO:0044212 [transcription regulatory region DNA binding] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular vesicular exosome] GO:0071169 [establishment of protein localization to chromatin] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter] GO:1902750 [negative regulation of cell cycle G2/M phase transition]	372	39.6	No	0
H2AFY-002	ENSP00000310169 ENST00000312469	O75367 Show all » « Hide O75367 [Direct mapping] Core histone macro-H2A.1	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000182 [rDNA binding] GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0001739 [sex chromatin] GO:0001740 [Barr body] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005721 [pericentric heterochromatin] GO:0005730 [nucleolus] GO:0006334 [nucleosome assembly] GO:0007549 [dosage compensation] GO:0010385 [double-stranded methylated DNA binding] GO:0016568 [chromatin modification] GO:0019901 [protein kinase binding] GO:0030291 [protein serine/threonine kinase inhibitor activity] GO:0031490 [chromatin DNA binding] GO:0033128 [negative regulation of histone phosphorylation] GO:0035098 [ESC/E(Z) complex] GO:0044212 [transcription regulatory region DNA binding] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular vesicular exosome] GO:0071169 [establishment of protein localization to chromatin] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter] GO:1902750 [negative regulation of cell cycle G2/M phase transition]	369	39.2	No	0
H2AFY-003	ENSP00000415121 ENST00000423969	B4DJC3 Show all » « Hide B4DJC3 [Target identity:100%; Query identity:100%] Histone H2A {ECO:0000256\|RuleBase:RU000527}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000786 [nucleosome] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046982 [protein heterodimerization activity]	200	21.5	No	0
H2AFY-004	ENSP00000302572 ENST00000304332	O75367 Show all » « Hide O75367 [Direct mapping] Core histone macro-H2A.1	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000182 [rDNA binding] GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0001739 [sex chromatin] GO:0001740 [Barr body] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005721 [pericentric heterochromatin] GO:0005730 [nucleolus] GO:0006334 [nucleosome assembly] GO:0007549 [dosage compensation] GO:0010385 [double-stranded methylated DNA binding] GO:0016568 [chromatin modification] GO:0019901 [protein kinase binding] GO:0030291 [protein serine/threonine kinase inhibitor activity] GO:0031490 [chromatin DNA binding] GO:0033128 [negative regulation of histone phosphorylation] GO:0035098 [ESC/E(Z) complex] GO:0044212 [transcription regulatory region DNA binding] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular vesicular exosome] GO:0071169 [establishment of protein localization to chromatin] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter] GO:1902750 [negative regulation of cell cycle G2/M phase transition]	371	39.5	No	0
H2AFY-005	ENSP00000424971 ENST00000510038	O75367 Show all » « Hide O75367 [Direct mapping] Core histone macro-H2A.1	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000182 [rDNA binding] GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0001739 [sex chromatin] GO:0001740 [Barr body] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005721 [pericentric heterochromatin] GO:0005730 [nucleolus] GO:0006334 [nucleosome assembly] GO:0007549 [dosage compensation] GO:0010385 [double-stranded methylated DNA binding] GO:0016568 [chromatin modification] GO:0019901 [protein kinase binding] GO:0030291 [protein serine/threonine kinase inhibitor activity] GO:0031490 [chromatin DNA binding] GO:0033128 [negative regulation of histone phosphorylation] GO:0035098 [ESC/E(Z) complex] GO:0044212 [transcription regulatory region DNA binding] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular vesicular exosome] GO:0071169 [establishment of protein localization to chromatin] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter] GO:1902750 [negative regulation of cell cycle G2/M phase transition]	372	39.6	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.