KNG1

GENE INFORMATION

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Gene name

KNG1 (HGNC Symbol)

Synonyms

BDK, BK, KNG

Description

Kininogen 1 (HGNC Symbol)

Entrez gene summary

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]

Chromosome

3

Cytoband

q27.3

Chromosome location (bp)

186717276 - 186743954

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113889 (version 78.38)

Entrez gene

3827

UniProt

P01042 (UniProt - Evidence at protein level)

neXtProt

NX_P01042

Antibodypedia

KNG1 antibodies
 

PROTEIN VIEW

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KNG1-001
 
KNG1-002
 
KNG1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KNG1-001 ENSP00000287611
ENST00000287611
P01042
Show all »
Show » Show » 427 47.9 Yes 0
KNG1-002 ENSP00000265023
ENST00000265023
P01042
Show all »
Show » Show » 644 72 Yes 0
KNG1-004 ENSP00000396025
ENST00000447445
P01042
Show all »
Show » Show » 391 43.8 Yes 0