UPK1B

GENE INFORMATION

? »

Gene name

UPK1B (HGNC Symbol)

Synonyms

TSPAN20, UPK1

Description

Uroplakin 1B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q13.32

Chromosome location (bp)

119173517 - 119205153

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114638 (version 78.38)

Entrez gene

7348

UniProt

O75841 (UniProt - Evidence at transcript level)

neXtProt

NX_O75841

Antibodypedia

UPK1B antibodies
 

PROTEIN VIEW

? »
 
 
 
UPK1B-001
 
UPK1B-002
 
UPK1B-003
 
UPK1B-004
 
UPK1B-005
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UPK1B-001 ENSP00000264234
ENST00000264234
O75841
Show all »
Show » Show » 260 29.6 No 4
UPK1B-002 ENSP00000418972
ENST00000497685
E7ETN9
Show all »
Show » Show » 180 21.1 Yes 1
UPK1B-003 ENSP00000418116
ENST00000460625
C9J9M7
Show all »
Show » Show » 252 28.7 No 4
UPK1B-004 ENSP00000418399
ENST00000479520
C9J6N2
Show all »
Show » Show » 169 18.9 No 3
UPK1B-005 ENSP00000418597
ENST00000494855
C9J027
Show all »
Show » Show » 189 21.4 No 3