TTL

GENE INFORMATION

? »

Gene name

TTL (HGNC Symbol)

Synonyms

MGC46235

Description

Tubulin tyrosine ligase (HGNC Symbol)

Entrez gene summary

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

Chromosome

2

Cytoband

q14.1

Chromosome location (bp)

112482154 - 112541739

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114999 (version 78.38)

Entrez gene

150465

UniProt

Q8NG68 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NG68

Antibodypedia

TTL antibodies
 

PROTEIN VIEW

? »
 
 
 
TTL-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TTL-001 ENSP00000233336
ENST00000233336
Q8NG68
Show all »
Show » Show » 377 43.2 No 0