IL1A

GENE INFORMATION

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Gene name

IL1A (HGNC Symbol)

Synonyms

IL-1A, IL1, IL1-ALPHA, IL1F1

Description

Interleukin 1, alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.1

Chromosome location (bp)

112773915 - 112784590

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115008 (version 78.38)

Entrez gene

3552

UniProt

P01583 (UniProt - Evidence at protein level)

neXtProt

NX_P01583

Antibodypedia

IL1A antibodies
 

PROTEIN VIEW

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IL1A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL1A-001 ENSP00000263339
ENST00000263339
P01583
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