PCSK4

GENE INFORMATION

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Gene name

PCSK4 (HGNC Symbol)

Synonyms

DKFZp434B217, MGC34749, PC4, SPC5

Description

Proprotein convertase subtilisin/kexin type 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

1481428 - 1490752

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000115257 (version 78.38)

Entrez gene

54760

UniProt

Q6UW60 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6UW60

Antibodypedia

PCSK4 antibodies
 

PROTEIN VIEW

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PCSK4-001
 
PCSK4-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCSK4-001 ENSP00000300954
ENST00000300954
Q6UW60
Show all »
Show » Show » 755 82.8 Yes 1
PCSK4-010 ENSP00000466742
ENST00000588671
K7EN14
Show all »
Show » Show » 230 26.4 Yes 0