AUP1

GENE INFORMATION

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Gene name

AUP1

Synonyms

Description

Ancient ubiquitous protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

2

Cytoband

p13.1

Chromosome location (bp)

74526645 - 74529939

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115307 (version 78.38)

Entrez gene

550

UniProt

Q9Y679 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y679

Antibodypedia

AUP1 antibodies
 

PROTEIN VIEW

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AUP1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AUP1-001 ENSP00000366748
ENST00000377526
Q9Y679
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