STAT1 - Gene info - The Human Protein Atlas

Gene name

STAT1 (HGNC Symbol)

Synonyms

ISGF-3, STAT91

Description

Signal transducer and activator of transcription 1, 91kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q32.2

Chromosome location (bp)

190964358 - 191020960

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115415 (version 78.38)

Entrez gene

6772

UniProt

P42224 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT1-001

ENSP00000354394
ENST00000361099

P42224
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P42224 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
E7EPD2 [Target identity:24%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000402548}
E7ENM1 [Target identity:20%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000411398}
E9PH66 [Target identity:9%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000416019}
Q67C41 [Target identity:5%; Query identity:100%]
Signal transducer and activator of transcription 1 variant a {ECO:0000313|EMBL:AAR13284.1}

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Predicted intracellular proteins
Plasma proteins
Transcription factors
Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000983 [RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0007584 [response to nutrient]
GO:0008015 [blood circulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009612 [response to mechanical stimulus]
GO:0009617 [response to bacterium]
GO:0014070 [response to organic cyclic compound]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031730 [CCR5 chemokine receptor binding]
GO:0032496 [response to lipopolysaccharide]
GO:0032869 [cellular response to insulin stimulus]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0034240 [negative regulation of macrophage fusion]
GO:0035458 [cellular response to interferon-beta]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043330 [response to exogenous dsRNA]
GO:0043434 [response to peptide hormone]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051591 [response to cAMP]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0061326 [renal tubule development]
GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation]

750

87.3

STAT1-002

ENSP00000376137
ENST00000392323

J3KPM9
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J3KPM9 [Target identity:100%; Query identity:100%]
Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415}
E7EPD2 [Target identity:25%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000402548}
E7ENM1 [Target identity:21%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000411398}
E9PH66 [Target identity:9%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000416019}
Q67C41 [Target identity:5%; Query identity:100%]
Signal transducer and activator of transcription 1 variant a {ECO:0000313|EMBL:AAR13284.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]

714

83.4

STAT1-003

ENSP00000376136
ENST00000392322

P42224
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P42224 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
E7EPD2 [Target identity:25%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000402548}
E7ENM1 [Target identity:21%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000411398}
E9PH66 [Target identity:9%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000416019}
Q67C41 [Target identity:5%; Query identity:100%]
Signal transducer and activator of transcription 1 variant a {ECO:0000313|EMBL:AAR13284.1}

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000983 [RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0008015 [blood circulation]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0035458 [cellular response to interferon-beta]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043434 [response to peptide hormone]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051591 [response to cAMP]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0061326 [renal tubule development]
GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation]

712

STAT1-004

ENSP00000402548
ENST00000424722

E7EPD2
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E7EPD2 [Target identity:100%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000402548}
E7ENM1 [Target identity:83%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000411398}
E9PH66 [Target identity:38%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000416019}
Q67C41 [Target identity:23%; Query identity:100%]
Signal transducer and activator of transcription 1 variant a {ECO:0000313|EMBL:AAR13284.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]

180

21.8

STAT1-007

ENSP00000416019
ENST00000432058

E9PH66
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E9PH66 [Target identity:98%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000416019}
Q67C41 [Target identity:60%; Query identity:100%]
Signal transducer and activator of transcription 1 variant a {ECO:0000313|EMBL:AAR13284.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0004871 [signal transducer activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]

8.6

STAT1-008

ENSP00000411398
ENST00000454414

E7ENM1
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E7ENM1 [Target identity:100%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000411398}
E9PH66 [Target identity:46%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000416019}
Q67C41 [Target identity:28%; Query identity:100%]
Signal transducer and activator of transcription 1 variant a {ECO:0000313|EMBL:AAR13284.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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150

18.1

STAT1-011

ENSP00000386244
ENST00000409465

P42224
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Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000983 [RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0008015 [blood circulation]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0035458 [cellular response to interferon-beta]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043434 [response to peptide hormone]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051591 [response to cAMP]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0061326 [renal tubule development]
GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation]

750

87.3

STAT1-201

ENSP00000438703
ENST00000540176

D2KFR9
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D2KFR9 [Target identity:100%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000394512}; Truncated signal transducer and activator of transcription 1 {ECO:0000313|EMBL:ADA59517.1}
E7EPD2 [Target identity:93%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000402548}
E7ENM1 [Target identity:77%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000411398}
E9PH66 [Target identity:35%; Query identity:100%]
Signal transducer and activator of transcription 1-alpha/beta {ECO:0000313|Ensembl:ENSP00000416019}
Q67C41 [Target identity:21%; Query identity:100%]
Signal transducer and activator of transcription 1 variant a {ECO:0000313|EMBL:AAR13284.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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193

23.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.