SF3B1

GENE INFORMATION

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Gene name

SF3B1 (HGNC Symbol)

Synonyms

Hsh155, Prp10, PRPF10, SAP155, SF3b155

Description

Splicing factor 3b, subunit 1, 155kDa (HGNC Symbol)

Entrez gene summary

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q33.1

Chromosome location (bp)

197389784 - 197435091

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115524 (version 78.38)

Entrez gene

23451

UniProt

O75533 (UniProt - Evidence at protein level)

neXtProt

NX_O75533

Antibodypedia

SF3B1 antibodies
 

PROTEIN VIEW

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SF3B1-001
 
SF3B1-004
 
SF3B1-005
 
SF3B1-012
 
SF3B1-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SF3B1-001 ENSP00000335321
ENST00000335508
O75533
Show all »
Show » Show » 1304 145.8 No 2
SF3B1-004 ENSP00000419896
ENST00000487698
B4DGZ4
Show all »
Show » Show » 154 17.4 No 0
SF3B1-005 ENSP00000428820
ENST00000409915
O75533
Show all »
Show » Show » 144 16 No 0
SF3B1-012 ENSP00000409435
ENST00000424674
Show » Show » 241 27.2 No 0
SF3B1-014 ENSP00000402997
ENST00000414963
O75533
Show all »
Show » Show » 144 16 No 0