TPO

GENE INFORMATION

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Gene name

TPO (HGNC Symbol)

Synonyms

TPX

Description

Thyroid peroxidase (HGNC Symbol)

Entrez gene summary

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Chromosome

2

Cytoband

p25.3

Chromosome location (bp)

1374223 - 1543711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115705 (version 78.38)

Entrez gene

7173

UniProt

P07202 (UniProt - Evidence at protein level)

neXtProt

NX_P07202

Antibodypedia

TPO antibodies
 

PROTEIN VIEW

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 « 
 
TPO-001
 
TPO-002
 
TPO-004
 
TPO-005
 
TPO-006
 
TPO-007
 
TPO-009
 
TPO-010
 
TPO-012
 
TPO-201
 
TPO-202
 
TPO-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPO-001 ENSP00000329869
ENST00000329066
P07202
Show all »
Show » Show » 933 103 Yes 1
TPO-002 ENSP00000371636
ENST00000382201
P07202
Show all »
Show » Show » 876 96.7 Yes 1
TPO-004 ENSP00000405788
ENST00000422464
H0Y6H4
Show all »
Show » Show » 864 95.2 No 1
TPO-005 ENSP00000371633
ENST00000382198
P07202
Show all »
Show » Show » 760 84.6 Yes 1
TPO-006 ENSP00000371704
ENST00000382269
E9PFM6
Show all »
Show » Show » 174 19.3 Yes 0
TPO-007 ENSP00000400033
ENST00000446278
Show » Show » 404 45.1 No 1
TPO-009 ENSP00000389659
ENST00000425083
H7BZH8
Show all »
Show » Show » 154 16.2 No 1
TPO-010 ENSP00000390994
ENST00000423320
C9J511
Show all »
Show » Show » 172 19 Yes 0
TPO-012 ENSP00000419461
ENST00000469607
H7C5B6
Show all »
Show » Show » 363 40.7 No 1
TPO-201 ENSP00000318820
ENST00000345913
P07202
Show all »
Show » Show » 933 103 Yes 1
TPO-202 ENSP00000263886
ENST00000346956
P07202
Show all »
Show » Show » 889 98.3 Yes 1
TPO-203 ENSP00000444840
ENST00000539820
E9PFM6
Show all »
Show » Show » 174 19.3 Yes 0