PROC

GENE INFORMATION

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Gene name

PROC

Synonyms

Description

Protein C (inactivator of coagulation factors Va and VIIIa) (HGNC Symbol)

Entrez gene summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

Chromosome

2

Cytoband

q14.3

Chromosome location (bp)

127418427 - 127429246

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115718 (version 78.38)

Entrez gene

5624

UniProt

P04070 (UniProt - Evidence at protein level)

neXtProt

NX_P04070

Antibodypedia

PROC antibodies
 

PROTEIN VIEW

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PROC-001
 
PROC-002
 
PROC-003
 
PROC-006
 
PROC-010
 
PROC-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PROC-001 ENSP00000234071
ENST00000234071
P04070
Show all »
Show » Show » 461 52.1 Yes 0
PROC-002 ENSP00000386679
ENST00000409048
E7END6
Show all »
Show » Show » 495 55.4 Yes 0
PROC-003 ENSP00000412697
ENST00000429925
E7EVH6
Show all »
Show » Show » 126 14.1 Yes 0
PROC-006 ENSP00000406295
ENST00000427769
E7EU72
Show all »
Show » Show » 116 13 Yes 0
PROC-010 ENSP00000411241
ENST00000442644
E7ENR9
Show all »
Show » Show » 175 19.9 Yes 0
PROC-012 ENSP00000384225
ENST00000402125
Q6V7X9
Show all »
Show » Show » 236 26.3 No 0