PRKD3

GENE INFORMATION

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Gene name

PRKD3 (HGNC Symbol)

Synonyms

EPK2, PRKCN

Description

Protein kinase D3 (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p22.2

Chromosome location (bp)

37250502 - 37324808

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115825 (version 78.38)

Entrez gene

23683

UniProt

O94806 (UniProt - Evidence at protein level)

neXtProt

NX_O94806

Antibodypedia

PRKD3 antibodies
 

PROTEIN VIEW

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PRKD3-001
 
PRKD3-004
 
PRKD3-007
 
PRKD3-008
 
PRKD3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKD3-001 ENSP00000368356
ENST00000379066
O94806
Show all »
Show » Show » 890 100.5 No 0
PRKD3-004 ENSP00000401839
ENST00000443187
C9JKP8
Show all »
Show » Show » 181 20.7 No 0
PRKD3-007 ENSP00000398743
ENST00000443977
H7C172
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Show » Show » 173 18.9 No 0
PRKD3-008 ENSP00000399540
ENST00000452104
Show » Show » 185 20.6 No 0
PRKD3-201 ENSP00000234179
ENST00000234179
O94806
Show all »
Show » Show » 890 100.5 No 0