COX7A2L

GENE INFORMATION

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Gene name

COX7A2L (HGNC Symbol)

Synonyms

COX7AR, COX7RP, EB1, SIG81

Description

Cytochrome c oxidase subunit VIIa polypeptide 2 like (HGNC Symbol)

Entrez gene summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p21

Chromosome location (bp)

42333546 - 42425088

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115944 (version 78.38)

Entrez gene

9167

UniProt

O14548 (UniProt - Evidence at protein level)

neXtProt

NX_O14548

Antibodypedia

COX7A2L antibodies
 

PROTEIN VIEW

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COX7A2L-001
 
COX7A2L-007
 
COX7A2L-008
 
COX7A2L-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COX7A2L-001 ENSP00000367938
ENST00000378669
O14548
Show all »
Show » Show » 114 12.6 No 1
COX7A2L-007 ENSP00000431039
ENST00000463055
E5RJZ1
Show all »
Show » Show » 79 8.8 No 0
COX7A2L-008 ENSP00000429237
ENST00000468711
H0YBD2
Show all »
Show » Show » 95 10.4 No 0
COX7A2L-201 ENSP00000234301
ENST00000234301
O14548
Show all »
Show » Show » 114 12.6 No 1