NFE2L2 - Gene info - The Human Protein Atlas

Gene name

NFE2L2 (HGNC Symbol)

Synonyms

NRF2

Description

Nuclear factor, erythroid 2-like 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

Cytoband

q31.2

Chromosome location (bp)

177227595 - 177392697

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116044 (version 78.38)

Entrez gene

4780

UniProt

Q16236 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFE2L2-001

ENSP00000380252
ENST00000397062

Q16236
Show all » « Hide

Q16236 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
C9J1A8 [Target identity:46%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000400073}
C9J0Y1 [Target identity:38%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000412191}
K7ER33 [Target identity:24%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000468089}
Q9BZF8 [Target identity:4%; Query identity:100%]
NF-E2-related factor 2 {ECO:0000313|EMBL:AAK01657.1}

Show » « Hide

Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001221 [transcription cofactor binding]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019904 [protein domain specific binding]
GO:0030194 [positive regulation of blood coagulation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034599 [cellular response to oxidative stress]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045995 [regulation of embryonic development]
GO:0060548 [negative regulation of cell death]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:2000121 [regulation of removal of superoxide radicals]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]

605

67.8

NFE2L2-002

ENSP00000380253
ENST00000397063

Q16236
Show all » « Hide

Q16236 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
C9J1A8 [Target identity:47%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000400073}
C9J0Y1 [Target identity:39%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000412191}
K7ER33 [Target identity:24%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000468089}

Show » « Hide

GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019904 [protein domain specific binding]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:2000352 [negative regulation of endothelial cell apoptotic process]

589

66.1

NFE2L2-003

ENSP00000467401
ENST00000464747

Q16236
Show all » « Hide

Show » « Hide

589

66.1

NFE2L2-006

ENSP00000410015
ENST00000423513

C9JFL6
Show all » « Hide

C9JFL6 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000410015}

Show » « Hide

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)

141

16.9

NFE2L2-008

ENSP00000411575
ENST00000446151

Q16236
Show all » « Hide

Q16236 [Direct mapping]
Nuclear factor erythroid 2-related factor 2

Show » « Hide

582

65.4

NFE2L2-009

ENSP00000412191
ENST00000421929

C9J0Y1
Show all » « Hide

C9J0Y1 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000412191}
K7ER33 [Target identity:62%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000468089}

Show » « Hide

GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]

234

26.7

NFE2L2-010

ENSP00000391291
ENST00000430047

C9J3K4
Show all » « Hide

C9J3K4 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000391291}

Show » « Hide

7.6

NFE2L2-012

ENSP00000391590
ENST00000449627

C9JBM0
Show all » « Hide

C9JBM0 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000391590}

Show » « Hide

GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]

265

30.2

NFE2L2-013

ENSP00000400073
ENST00000448782

C9J1A8
Show all » « Hide

C9J1A8 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000400073}
C9J0Y1 [Target identity:83%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000412191}
K7ER33 [Target identity:52%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000468089}

Show » « Hide

GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]

280

31.7

NFE2L2-014

ENSP00000416308
ENST00000458603

H7C498
Show all » « Hide

H7C498 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000416308}

Show » « Hide

5.4

NFE2L2-015

ENSP00000468089
ENST00000588123

K7ER33
Show all » « Hide

K7ER33 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000468089}

Show » « Hide

146

16.9

NFE2L2-016

ENSP00000464920
ENST00000586532

K7EIW5
Show all » « Hide

K7EIW5 [Target identity:100%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000464920}
C9J0Y1 [Target identity:88%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000412191}
K7ER33 [Target identity:55%; Query identity:100%]
Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSP00000468089}

Show » « Hide

GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]

265

30.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.