PLA2G4A

GENE INFORMATION

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Gene name

PLA2G4A (HGNC Symbol)

Synonyms

cPLA2-alpha, PLA2G4

Description

Phospholipase A2, group IVA (cytosolic, calcium-dependent) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q31.1

Chromosome location (bp)

186828953 - 186988981

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116711 (version 78.38)

Entrez gene

5321

UniProt

P47712 (UniProt - Evidence at protein level)

neXtProt

NX_P47712

Antibodypedia

PLA2G4A antibodies
 

PROTEIN VIEW

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PLA2G4A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLA2G4A-001 ENSP00000356436
ENST00000367466
P47712
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