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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| KDM5B-001 |
ENSP00000356234
ENST00000367265
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Q9UGL1
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Q9UGL1 [Direct mapping]Lysine-specific demethylase 5B Q9UFD3 [Target identity:87%; Query identity:100%]Putative uncharacterized protein DKFZp434N0335 {ECO:0000313|EMBL:CAB61368.1} B3KV94 [Target identity:82%; Query identity:100%]Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a {ECO:0000313|EMBL:EAW91432.1}; Lysine-specific demethylase 5B {ECO:0000313|Ensembl:ENSP00000235790}; cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA {ECO:0000313|EMBL:BAG53706.1} B3KMS8 [Target identity:67%; Query identity:100%]cDNA FLJ12491 fis, clone NT2RM2001605, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA {ECO:0000313|EMBL:BAG51090.1} Q9UFC7 [Target identity:66%; Query identity:100%]Putative uncharacterized protein DKFZp434D0815 {ECO:0000313|EMBL:CAB61375.1} Q9UIW7 [Target identity:59%; Query identity:100%]Putative uncharacterized protein DKFZp434I0617 {ECO:0000313|EMBL:CAB61395.1} Q9NSZ7 [Target identity:40%; Query identity:100%]Putative uncharacterized protein DKFZp434I2412 {ECO:0000313|EMBL:CAB70847.1} B3KMS2 [Target identity:26%; Query identity:100%]cDNA FLJ12459 fis, clone NT2RM1000691, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA {ECO:0000313|EMBL:BAG51084.1} Q6UGB8 [Target identity:4%; Query identity:100%]Putative DNA/chromatin binding motif {ECO:0000313|EMBL:AAQ82849.1}
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THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0034647 [histone demethylase activity (H3-trimethyl-K4 specific)] GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0034721 [histone H3-K4 demethylation, trimethyl-H3-K4-specific] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process]
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1544 |
175.7 |
No |
0 |
| KDM5B-002 |
ENSP00000235790
ENST00000235790
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B3KV94
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B3KV94 [Target identity:100%; Query identity:100%]Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a {ECO:0000313|EMBL:EAW91432.1}; Lysine-specific demethylase 5B {ECO:0000313|Ensembl:ENSP00000235790}; cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA {ECO:0000313|EMBL:BAG53706.1} B3KMS8 [Target identity:81%; Query identity:100%]cDNA FLJ12491 fis, clone NT2RM2001605, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA {ECO:0000313|EMBL:BAG51090.1}
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THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0055114 [oxidation-reduction process]
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1275 |
145.1 |
No |
0 |
| KDM5B-003 |
ENSP00000356233
ENST00000367264
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Q9UGL1
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Q9UGL1 [Direct mapping]Lysine-specific demethylase 5B B3KMS8 [Target identity:65%; Query identity:100%]cDNA FLJ12491 fis, clone NT2RM2001605, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA {ECO:0000313|EMBL:BAG51090.1} Q9UFC7 [Target identity:65%; Query identity:100%]Putative uncharacterized protein DKFZp434D0815 {ECO:0000313|EMBL:CAB61375.1} Q9UIW7 [Target identity:57%; Query identity:100%]Putative uncharacterized protein DKFZp434I0617 {ECO:0000313|EMBL:CAB61395.1} Q9NSZ7 [Target identity:39%; Query identity:100%]Putative uncharacterized protein DKFZp434I2412 {ECO:0000313|EMBL:CAB70847.1} B3KMS2 [Target identity:25%; Query identity:100%]cDNA FLJ12459 fis, clone NT2RM1000691, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA {ECO:0000313|EMBL:BAG51084.1} Q6UGB8 [Target identity:4%; Query identity:100%]Putative DNA/chromatin binding motif {ECO:0000313|EMBL:AAQ82849.1}
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Show »
« Hide
THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0034647 [histone demethylase activity (H3-trimethyl-K4 specific)] GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0034721 [histone H3-K4 demethylation, trimethyl-H3-K4-specific] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process]
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1580 |
179.4 |
No |
0 |
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