CD46 - Gene info - The Human Protein Atlas

CD46

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CD46 (HGNC Symbol)
Synonyms	MCP, MGC26544, MIC10, TLX, TRA2.10
Description	CD46 molecule, complement regulatory protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	207752057 - 207795513
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117335 (version 78.38)
Entrez gene	4179
UniProt	P15529 (UniProt - Evidence at protein level)
neXtProt	NX_P15529
Antibodypedia	CD46 antibodies

PROTEIN VIEW

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CD46-001		CD46-002		CD46-003		CD46-004		CD46-005		CD46-006		CD46-007		CD46-008		CD46-011		CD46-012		CD46-013

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CD46-001	ENSP00000350893 ENST00000358170	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:8%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	392	43.7	Yes	1
CD46-002	ENSP00000346912 ENST00000354848	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:8%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	384	42.7	Yes	1
CD46-003	ENSP00000314664 ENST00000322918	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:9%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	349	39.3	Yes	1
CD46-004	ENSP00000356009 ENST00000367042	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:9%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	377	42.2	Yes	1
CD46-005	ENSP00000356008 ENST00000367041	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:9%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	362	40.9	Yes	1
CD46-006	ENSP00000350346 ENST00000357714	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:9%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	369	41.4	Yes	1
CD46-007	ENSP00000313875 ENST00000322875	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:8%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001669 [acrosomal vesicle] GO:0001848 [complement binding] GO:0002079 [inner acrosomal membrane] GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004175 [endopeptidase activity] GO:0004857 [enzyme inhibitor activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0016323 [basolateral plasma membrane] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043086 [negative regulation of catalytic activity] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0045916 [negative regulation of complement activation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	399	44.2	Yes	1
CD46-008	ENSP00000356014 ENST00000367047	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	336	36.8	Yes	1
CD46-011	ENSP00000473449 ENST00000462968		Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		78	8.4	No	1
CD46-012	ENSP00000353342 ENST00000360212	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:9%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	355	39.8	Yes	1
CD46-013	ENSP00000418471 ENST00000480003	P15529 Show all » « Hide P15529 [Direct mapping] Membrane cofactor protein Q06C42 [Target identity:9%; Query identity:100%] Complement system membrane cofactor protein CD46 {ECO:0000313\|EMBL:ABI96986.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002250 [adaptive immune response] GO:0002456 [T cell mediated immunity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006958 [complement activation, classical pathway] GO:0007338 [single fertilization] GO:0008593 [regulation of Notch signaling pathway] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0032613 [interleukin-10 production] GO:0032733 [positive regulation of interleukin-10 production] GO:0035581 [sequestering of extracellular ligand from receptor] GO:0042102 [positive regulation of T cell proliferation] GO:0043382 [positive regulation of memory T cell differentiation] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0070062 [extracellular vesicular exosome] GO:0071636 [positive regulation of transforming growth factor beta production]	370	41.2	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.