B4GALT2

GENE INFORMATION

? »

Gene name

B4GALT2 (HGNC Symbol)

Synonyms

beta4Gal-T2

Description

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (HGNC Symbol)

Entrez gene summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

1

Cytoband

p34.1

Chromosome location (bp)

43978943 - 43991170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000117411 (version 78.38)

Entrez gene

8704

UniProt

O60909 (UniProt - Evidence at protein level)

neXtProt

NX_O60909

Antibodypedia

B4GALT2 antibodies
 

PROTEIN VIEW

? »
 
 
 
B4GALT2-001
 
B4GALT2-002
 
B4GALT2-201
 
B4GALT2-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

B4GALT2-001 ENSP00000349293
ENST00000356836
O60909
Show all »
Show » Show » 372 42 No 1
B4GALT2-002 ENSP00000407468
ENST00000434555
O60909
Show all »
Show » Show » 306 34.9 No 0
B4GALT2-201 ENSP00000310696
ENST00000309519
O60909
Show all »
Show » Show » 401 44.8 No 1
B4GALT2-202 ENSP00000361399
ENST00000372324
O60909
Show all »
Show » Show » 372 42 No 1