SERPINC1

GENE INFORMATION

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Gene name

SERPINC1 (HGNC Symbol)

Synonyms

AT3, ATIII, MGC22579

Description

Serpin peptidase inhibitor, clade C (antithrombin), member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

Chromosome

1

Cytoband

q25.1

Chromosome location (bp)

173903804 - 173917378

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000117601 (version 78.38)

Entrez gene

462

UniProt

P01008 (UniProt - Evidence at protein level)

neXtProt

NX_P01008

Antibodypedia

SERPINC1 antibodies
 

PROTEIN VIEW

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SERPINC1-001
 
SERPINC1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINC1-001 ENSP00000356671
ENST00000367698
P01008
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Show » Show » 464 52.6 Yes 0
SERPINC1-201 ENSP00000478688
ENST00000617423
Q8TCE1
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Show » 259 29.1 Yes 0