ARID1A

GENE INFORMATION

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Gene name

ARID1A (HGNC Symbol)

Synonyms

B120, BAF250, BAF250a, C10rf4, C1orf4, P270, SMARCF1

Description

AT rich interactive domain 1A (SWI-like) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.11

Chromosome location (bp)

26696033 - 26782104

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000117713 (version 78.38)

Entrez gene

8289

UniProt

O14497 (UniProt - Evidence at protein level)

neXtProt

NX_O14497

Antibodypedia

ARID1A antibodies
 

PROTEIN VIEW

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ARID1A-001
 
ARID1A-002
 
ARID1A-003
 
ARID1A-007
 
ARID1A-009
 
ARID1A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARID1A-001 ENSP00000320485
ENST00000324856
O14497
Show all »
Show » Show » 2285 242 No 0
ARID1A-002 ENSP00000387636
ENST00000457599
O14497
Show all »
Show » Show » 2068 218.3 No 0
ARID1A-003 ENSP00000363267
ENST00000374152
O14497
Show all »
Show » Show » 1902 205.9 No 0
ARID1A-007 ENSP00000432473
ENST00000524572
E9PQW6
Show all »
Show » 123 13.6 No 0
ARID1A-009 ENSP00000390317
ENST00000430799
Q96SM7
Show all »
Show » Show » 1182 129.4 No 0
ARID1A-201 ENSP00000478955
ENST00000615191
E9PQW6
Show all »
Show » Show » 1141 121.7 No 0