SPACA1

GENE INFORMATION

? »

Gene name

SPACA1 (HGNC Symbol)

Synonyms

SAMP32

Description

Sperm acrosome associated 1 (HGNC Symbol)

Entrez gene summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q15

Chromosome location (bp)

88047789 - 88066832

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118434 (version 78.38)

Entrez gene

81833

UniProt

Q9HBV2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HBV2

Antibodypedia

SPACA1 antibodies
 

PROTEIN VIEW

? »
 
 
 
SPACA1-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPACA1-002 ENSP00000237201
ENST00000237201
Q9HBV2
Show all »
Show » Show » 294 32.1 Yes 1