SET

GENE INFORMATION

? »

Gene name

SET (HGNC Symbol)

Synonyms

2PP2A, IPP2A2, PHAPII

Description

SET nuclear proto-oncogene (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

128683424 - 128696400

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119335 (version 78.38)

Entrez gene

6418

UniProt

Q01105 (UniProt - Evidence at protein level)

neXtProt

NX_Q01105

Antibodypedia

SET antibodies
 

PROTEIN VIEW

? »
 
 
 
SET-001
 
SET-002
 
SET-003
 
SET-009
 
SET-010
 
SET-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SET-001 ENSP00000361777
ENST00000372692
Q01105
Show all »
Show » Show » 290 33.5 No 0
SET-002 ENSP00000318012
ENST00000322030
A0A024R895
Show all »
Show » Show » 277 32.1 No 0
SET-003 ENSP00000387321
ENST00000409104
Show » Show » 268 31.3 No 0
SET-009 ENSP00000410806
ENST00000454747
B2REB7
Show all »
Show » 32 3.3 No 0
SET-010 ENSP00000361771
ENST00000372686
Show » Show » 265 31 No 0
SET-201 ENSP00000361773
ENST00000372688
Q01105
Show all »
Show » Show » 266 31.1 No 0