CPN1

GENE INFORMATION

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Gene name

CPN1

Synonyms

Description

Carboxypeptidase N, polypeptide 1 (HGNC Symbol)

Entrez gene summary

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q24.2

Chromosome location (bp)

100042193 - 100081877

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120054 (version 78.38)

Entrez gene

1369

UniProt

P15169 (UniProt - Evidence at protein level)

neXtProt

NX_P15169

Antibodypedia

CPN1 antibodies
 

PROTEIN VIEW

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CPN1-001
 
CPN1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CPN1-001 ENSP00000359446
ENST00000370418
P15169
Show all »
Show » Show » 458 52.3 Yes 0
CPN1-003 ENSP00000410895
ENST00000441382
B1AP58
Show all »
Show » Show » 204 22.9 No 0