TNFSF11

GENE INFORMATION

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Gene name

TNFSF11 (HGNC Symbol)

Synonyms

CD254, ODF, OPGL, RANKL, TRANCE

Description

Tumor necrosis factor (ligand) superfamily, member 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q14.11

Chromosome location (bp)

42562736 - 42608013

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120659 (version 78.38)

Entrez gene

8600

UniProt

O14788 (UniProt - Evidence at protein level)

neXtProt

NX_O14788

Antibodypedia

TNFSF11 antibodies
 

PROTEIN VIEW

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TNFSF11-001
 
TNFSF11-002
 
TNFSF11-201
 
TNFSF11-202
 
TNFSF11-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFSF11-001 ENSP00000381775
ENST00000398795
O14788
Show all »
Show » Show » 317 35.5 No 1
TNFSF11-002 ENSP00000351347
ENST00000358545
O14788
Show all »
Show » Show » 244 27.7 No 0
TNFSF11-201 ENSP00000239849
ENST00000239849
O14788
Show all »
Show » Show » 270 30.5 Yes 0
TNFSF11-202 ENSP00000384042
ENST00000405262
O14788
Show all »
Show » Show » 244 27.7 No 0
TNFSF11-203 ENSP00000444913
ENST00000544862
O14788
Show all »
Show » Show » 244 27.7 No 0