APAF1

GENE INFORMATION

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Gene name

APAF1 (HGNC Symbol)

Synonyms

APAF-1, CED4

Description

Apoptotic peptidase activating factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q23.1

Chromosome location (bp)

98645141 - 98735433

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120868 (version 78.38)

Entrez gene

317

UniProt

O14727 (UniProt - Evidence at protein level)

neXtProt

NX_O14727

Antibodypedia

APAF1 antibodies
 

PROTEIN VIEW

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APAF1-001
 
APAF1-002
 
APAF1-003
 
APAF1-004
 
APAF1-005
 
APAF1-006
 
APAF1-007
 
APAF1-201
 
APAF1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APAF1-001 ENSP00000353059
ENST00000359972
O14727
Show all »
Show » Show » 1194 136 No 0
APAF1-002 ENSP00000448165
ENST00000551964
O14727
Show all »
Show » Show » 1248 141.8 No 0
APAF1-003 ENSP00000448826
ENST00000552268
O14727
Show all »
Show » Show » 338 38 No 0
APAF1-004 ENSP00000448449
ENST00000550527
O14727
Show all »
Show » Show » 1237 140.7 No 0
APAF1-005 ENSP00000449791
ENST00000547045
O14727
Show all »
Show » Show » 1205 137.1 No 0
APAF1-006 ENSP00000448161
ENST00000549007
C9JLV4
Show all »
Show » Show » 1163 132.5 No 0
APAF1-007 ENSP00000450175
ENST00000547743
F8VNZ0
Show all »
Show » Show » 130 14.7 No 0
APAF1-201 ENSP00000334558
ENST00000333991
O14727
Show all »
Show » Show » 338 38 No 0
APAF1-202 ENSP00000349862
ENST00000357310
O14727
Show all »
Show » Show » 1205 137.1 No 0