RNF170

GENE INFORMATION

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Gene name

RNF170 (HGNC Symbol)

Synonyms

ADSA, DKFZP564A022, SNAX1

Description

Ring finger protein 170 (HGNC Symbol)

Entrez gene summary

This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Chromosome

8

Cytoband

p11.21

Chromosome location (bp)

42849637 - 42897290

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120925 (version 78.38)

Entrez gene

81790

UniProt

Q96K19 (UniProt - Evidence at protein level)

neXtProt

NX_Q96K19

Antibodypedia

RNF170 antibodies
 

PROTEIN VIEW

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RNF170-001
 
RNF170-003
 
RNF170-005
 
RNF170-006
 
RNF170-007
 
RNF170-201
 
RNF170-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RNF170-001 ENSP00000434797
ENST00000527424
Q96K19
Show all »
Show » Show » 258 29.8 No 3
RNF170-003 ENSP00000435782
ENST00000526349
Q96K19
Show all »
Show » Show » 174 20.3 No 2
RNF170-005 ENSP00000326138
ENST00000319104
Q96K19
Show all »
Show » Show » 200 22.2 No 1
RNF170-006 ENSP00000437146
ENST00000524954
E9PNG8
Show all »
Show » 45 4.8 No 1
RNF170-007 ENSP00000436416
ENST00000531440
E9PP55
Show all »
Show » Show » 115 13 No 1
RNF170-201 ENSP00000325969
ENST00000319073
Q96K19
Show all »
Show » Show » 116 13.1 No 1
RNF170-202 ENSP00000445725
ENST00000534961
Q96K19
Show all »
Show » Show » 258 29.8 No 3