TNFRSF8

GENE INFORMATION

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Gene name

TNFRSF8 (HGNC Symbol)

Synonyms

CD30, D1S166E, KI-1

Description

Tumor necrosis factor receptor superfamily, member 8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

12063377 - 12144207

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120949 (version 78.38)

Entrez gene

943

UniProt

P28908 (UniProt - Evidence at protein level)

neXtProt

NX_P28908

Antibodypedia

TNFRSF8 antibodies
 

PROTEIN VIEW

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TNFRSF8-001
 
TNFRSF8-002
 
TNFRSF8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF8-001 ENSP00000263932
ENST00000263932
P28908
Show all »
Show » Show » 595 63.7 Yes 1
TNFRSF8-002 ENSP00000398337
ENST00000413146
P28908
Show all »
Show » Show » 132 14.1 No 0
TNFRSF8-201 ENSP00000390650
ENST00000417814
P28908
Show all »
Show » Show » 483 50.9 No 1