PAEP

GENE INFORMATION

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Gene name

PAEP (HGNC Symbol)

Synonyms

GD, GdA, GdF, GdS, MGC138509, MGC142288, PAEG, PEP, PP14

Description

Progestagen-associated endometrial protein (HGNC Symbol)

Entrez gene summary

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. A number of alternatively spliced transcript variants have been observed at this locus, but the full-length nature of only two, each encoding the same protein, has been determined. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.3

Chromosome location (bp)

135561756 - 135566955

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122133 (version 78.38)

Entrez gene

5047

UniProt

P09466 (UniProt - Evidence at protein level)

neXtProt

NX_P09466

Antibodypedia

PAEP antibodies
 

PROTEIN VIEW

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PAEP-001
 
PAEP-002
 
PAEP-003
 
PAEP-005
 
PAEP-006
 
PAEP-007
 
PAEP-008
 
PAEP-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAEP-001 ENSP00000417898
ENST00000479141
P09466
Show all »
Show » Show » 180 20.6 Yes 0
PAEP-002 ENSP00000360831
ENST00000371766
P09466
Show all »
Show » Show » 180 20.6 Yes 0
PAEP-003 ENSP00000277508
ENST00000277508
P09466
Show all »
Show » Show » 180 20.6 Yes 0
PAEP-005 ENSP00000401933
ENST00000418284
Q5T6T6
Show all »
Show » Show » 132 15.5 No 0
PAEP-006 ENSP00000396196
ENST00000457014
Show » 33 4 No 0
PAEP-007 ENSP00000394216
ENST00000433563
Show » 131 15 No 0
PAEP-008 ENSP00000404033
ENST00000454923
Show » 126 14.8 No 0
PAEP-201 ENSP00000484659
ENST00000611414
A6XNE0
Show all »
Show » 143 16.4 Yes 0