RPL5

GENE INFORMATION

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Gene name

RPL5 (HGNC Symbol)

Synonyms

L5, PPP1R135

Description

Ribosomal protein L5 (HGNC Symbol)

Entrez gene summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p22.1

Chromosome location (bp)

92832025 - 92841924

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122406 (version 78.38)

Entrez gene

6125

UniProt

P46777 (UniProt - Evidence at protein level)

neXtProt

NX_P46777

Antibodypedia

RPL5 antibodies
 

PROTEIN VIEW

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RPL5-001
 
RPL5-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPL5-001 ENSP00000359345
ENST00000370321
P46777
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Show » Show » 297 34.4 No 0
RPL5-006 ENSP00000359338
ENST00000315741
Q5T7N0
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Show » Show » 130 14.1 No 0