CNTFR

GENE INFORMATION

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Gene name

CNTFR

Synonyms

Description

Ciliary neurotrophic factor receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

34551432 - 34590140

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122756 (version 78.38)

Entrez gene

1271

UniProt

P26992 (UniProt - Evidence at protein level)

neXtProt

NX_P26992

Antibodypedia

CNTFR antibodies
 

PROTEIN VIEW

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CNTFR-001
 
CNTFR-002
 
CNTFR-003
 
CNTFR-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNTFR-001 ENSP00000368265
ENST00000378980
P26992
Show all »
Show » Show » 372 40.6 Yes 1
CNTFR-002 ENSP00000242338
ENST00000351266
P26992
Show all »
Show » Show » 372 40.6 Yes 1
CNTFR-003 ENSP00000388082
ENST00000417345
Q5T8H6
Show all »
Show » Show » 256 28.8 Yes 0
CNTFR-201 ENSP00000480451
ENST00000610543
P26992
Show all »
Show » Show » 372 40.6 Yes 1