VPS26A

GENE INFORMATION

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Gene name

VPS26A (HGNC Symbol)

Synonyms

Hbeta58, PEP8A, VPS26

Description

Vacuolar protein sorting 26 homolog A (S. pombe) (HGNC Symbol)

Entrez gene summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q22.1

Chromosome location (bp)

69123512 - 69172861

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122958 (version 78.38)

Entrez gene

9559

UniProt

O75436 (UniProt - Evidence at protein level)

neXtProt

NX_O75436

Antibodypedia

VPS26A antibodies
 

PROTEIN VIEW

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VPS26A-001
 
VPS26A-002
 
VPS26A-201
 
VPS26A-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VPS26A-001 ENSP00000362480
ENST00000373382
O75436
Show all »
Show » Show » 327 38.2 No 0
VPS26A-002 ENSP00000474611
ENST00000489794
S4R3Q6
Show all »
Show » 226 26.2 No 0
VPS26A-201 ENSP00000263559
ENST00000263559
O75436
Show all »
Show » Show » 327 38.2 No 0
VPS26A-202 ENSP00000378532
ENST00000395098
O75436
Show all »
Show » Show » 251 28.9 No 0