OPTN

GENE INFORMATION

? »

Gene name

OPTN (HGNC Symbol)

Synonyms

FIP-2, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP

Description

Optineurin (HGNC Symbol)

Entrez gene summary

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

p13

Chromosome location (bp)

13099449 - 13138308

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123240 (version 78.38)

Entrez gene

10133

UniProt

Q96CV9 (UniProt - Evidence at protein level)

neXtProt

NX_Q96CV9

Antibodypedia

OPTN antibodies
 

PROTEIN VIEW

? »
 
 
 
OPTN-001
 
OPTN-004
 
OPTN-005
 
OPTN-006
 
OPTN-007
 
OPTN-008
 
OPTN-009
 
OPTN-012
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OPTN-001 ENSP00000400356
ENST00000424614
Show » 126 13.8 No 0
OPTN-004 ENSP00000368027
ENST00000378752
Q96CV9
Show all »
Show » Show » 571 65.2 No 0
OPTN-005 ENSP00000368022
ENST00000378748
Q96CV9
Show all »
Show » Show » 577 65.9 No 0
OPTN-006 ENSP00000263036
ENST00000263036
Q96CV9
Show all »
Show » Show » 577 65.9 No 0
OPTN-007 ENSP00000368032
ENST00000378757
Q96CV9
Show all »
Show » Show » 577 65.9 No 0
OPTN-008 ENSP00000368021
ENST00000378747
Q96CV9
Show all »
Show » Show » 577 65.9 No 0
OPTN-009 ENSP00000368040
ENST00000378764
Q96CV9
Show all »
Show » Show » 571 65.2 No 0
OPTN-012 ENSP00000481473
ENST00000486862
Show » 107 11.5 No 0