NR4A1 - Gene info - The Human Protein Atlas

NR4A1

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	NR4A1 (HGNC Symbol)
Synonyms	GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3
Description	Nuclear receptor subfamily 4, group A, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52022832 - 52059507
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123358 (version 78.38)
Entrez gene	3164
UniProt	P22736 (UniProt - Evidence at protein level)
neXtProt	NX_P22736
Antibodypedia	NR4A1 antibodies

PROTEIN VIEW

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NR4A1-002		NR4A1-003		NR4A1-004		NR4A1-006		NR4A1-010		NR4A1-011		NR4A1-012		NR4A1-013		NR4A1-016		NR4A1-021		NR4A1-201		NR4A1-202		NR4A1-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NR4A1-002	ENSP00000378301 ENST00000394824	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BPN8 [Target identity:25%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	598	64.5	No	0
NR4A1-003	ENSP00000440864 ENST00000545748	F5GXF0 Show all » « Hide F5GXF0 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000440864} A0A024R126 [Target identity:91%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BT85 [Target identity:46%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:23%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:18%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035914 [skeletal muscle cell differentiation] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071310 [cellular response to organic substance]	652	70.5	No	0
NR4A1-004	ENSP00000449539 ENST00000550082	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:97%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BT85 [Target identity:49%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:24%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:19%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	611	66	No	0
NR4A1-006	ENSP00000449587 ENST00000548232	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 H3BPN8 [Target identity:46%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	325	33.8	No	0
NR4A1-010	ENSP00000456776 ENST00000553200	H3BSM8 Show all » « Hide H3BSM8 [Target identity:98%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456776}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		79	8.5	No	0
NR4A1-011	ENSP00000456633 ENST00000548977	H3BSB9 Show all » « Hide H3BSB9 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0030522 [intracellular receptor signaling pathway]	119	12.5	No	0
NR4A1-012	ENSP00000457070 ENST00000546842	H3BT85 Show all » « Hide H3BT85 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:49%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:39%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043565 [sequence-specific DNA binding]	302	31.3	No	0
NR4A1-013	ENSP00000449858 ENST00000550763	F8VVX9 Show all » « Hide F8VVX9 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000449858}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030522 [intracellular receptor signaling pathway]	148	15.6	No	0
NR4A1-016	ENSP00000455767 ENST00000550582	H3BQG5 Show all » « Hide H3BQG5 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455767}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		120	12.5	No	0
NR4A1-021	ENSP00000455399 ENST00000562373	H3BPN8 Show all » « Hide H3BPN8 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0030522 [intracellular receptor signaling pathway]	150	15.5	No	0
NR4A1-201	ENSP00000243050 ENST00000243050	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BPN8 [Target identity:25%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	598	64.5	No	0
NR4A1-202	ENSP00000353427 ENST00000360284	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:97%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BT85 [Target identity:49%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:24%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:19%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	611	66	No	0
NR4A1-203	ENSP00000378302 ENST00000394825	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BPN8 [Target identity:25%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	598	64.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.