PLP1

GENE INFORMATION

? »

Gene name

PLP1 (HGNC Symbol)

Synonyms

GPM6C, PLP, SPG2

Description

Proteolipid protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q22.2

Chromosome location (bp)

103773718 - 103792619

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123560 (version 78.38)

Entrez gene

5354

UniProt

P60201 (UniProt - Evidence at protein level)

neXtProt

NX_P60201

Antibodypedia

PLP1 antibodies
 

PROTEIN VIEW

? »
 
 
 
PLP1-001
 
PLP1-002
 
PLP1-004
 
PLP1-005
 
PLP1-006
 
PLP1-007
 
PLP1-008
 
PLP1-009
 
PLP1-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLP1-001 ENSP00000484450
ENST00000621218
P60201
Show all »
Show » Show » 277 30.1 No 4
PLP1-002 ENSP00000477619
ENST00000619236
P60201
Show all »
Show » Show » 242 26.3 No 4
PLP1-004 ENSP00000403335
ENST00000434483
B1B1G3
Show all »
Show » Show » 123 13.3 No 2
PLP1-005 ENSP00000480409
ENST00000494475
B1B1G6
Show all »
Show » Show » 137 14.9 No 2
PLP1-006 ENSP00000409802
ENST00000455268
B1B1G6
Show all »
Show » Show » 136 14.7 No 2
PLP1-007 ENSP00000413931
ENST00000422393
B1B1G4
Show all »
Show » Show » 127 13.7 No 2
PLP1-008 ENSP00000393391
ENST00000433491
B1B1G1
Show all »
Show » Show » 100 11 No 2
PLP1-009 ENSP00000391853
ENST00000443502
B1B1G2
Show all »
Show » Show » 112 12.3 No 2
PLP1-201 ENSP00000481006
ENST00000612423
P60201
Show all »
Show » Show » 277 30.1 No 4