SERPINA7

GENE INFORMATION

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Gene name

SERPINA7 (HGNC Symbol)

Synonyms

TBG

Description

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (HGNC Symbol)

Entrez gene summary

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

Chromosome

X

Cytoband

q22.3

Chromosome location (bp)

106032442 - 106038738

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123561 (version 78.38)

Entrez gene

6906

UniProt

P05543 (UniProt - Evidence at protein level)

neXtProt

NX_P05543

Antibodypedia

SERPINA7 antibodies
 

PROTEIN VIEW

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SERPINA7-001
 
SERPINA7-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINA7-001 ENSP00000329374
ENST00000327674
P05543
Show all »
Show » Show » 415 46.3 Yes 0
SERPINA7-002 ENSP00000361644
ENST00000372563
P05543
Show all »
Show » Show » 415 46.3 Yes 0