ESX1

GENE INFORMATION

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Gene name

ESX1 (HGNC Symbol)

Synonyms

ESX1L, ESXR1

Description

ESX homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]

Chromosome

X

Cytoband

q22.2

Chromosome location (bp)

104250038 - 104254933

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123576 (version 78.38)

Entrez gene

80712

UniProt

Q8N693 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N693

Antibodypedia

ESX1 antibodies
 

PROTEIN VIEW

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ESX1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ESX1-001 ENSP00000361669
ENST00000372588
Q8N693
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