TNFAIP6

GENE INFORMATION

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Gene name

TNFAIP6 (HGNC Symbol)

Synonyms

TSG-6, TSG6

Description

Tumor necrosis factor, alpha-induced protein 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]

Chromosome

2

Cytoband

q23.3

Chromosome location (bp)

151357592 - 151380048

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123610 (version 78.38)

Entrez gene

7130

UniProt

P98066 (UniProt - Evidence at protein level)

neXtProt

NX_P98066

Antibodypedia

TNFAIP6 antibodies
 

PROTEIN VIEW

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TNFAIP6-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFAIP6-001 ENSP00000243347
ENST00000243347
P98066
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