PI3

GENE INFORMATION

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Gene name

PI3 (HGNC Symbol)

Synonyms

cementoin, ELAFIN, ESI, SKALP, WAP3, WFDC14

Description

Peptidase inhibitor 3, skin-derived (HGNC Symbol)

Entrez gene summary

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

45174876 - 45176544

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124102 (version 78.38)

Entrez gene

5266

UniProt

P19957 (UniProt - Evidence at protein level)

neXtProt

NX_P19957

Antibodypedia

PI3 antibodies
 

PROTEIN VIEW

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PI3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PI3-001 ENSP00000243924
ENST00000243924
P19957
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