CSE1L

GENE INFORMATION

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Gene name

CSE1L (HGNC Symbol)

Synonyms

CAS, CSE1, XPO2

Description

CSE1 chromosome segregation 1-like (yeast) (HGNC Symbol)

Entrez gene summary

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

49046246 - 49096960

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124207 (version 78.38)

Entrez gene

1434

UniProt

P55060 (UniProt - Evidence at protein level)

neXtProt

NX_P55060

Antibodypedia

CSE1L antibodies
 

PROTEIN VIEW

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CSE1L-001
 
CSE1L-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSE1L-001 ENSP00000262982
ENST00000262982
P55060
Show all »
Show » Show » 971 110.4 No 0
CSE1L-201 ENSP00000379495
ENST00000396192
P55060
Show all »
Show » Show » 915 103.9 No 0